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Keypath P16 Protein Marker ICC Immunoassay Test Kit Cervical Cancer Screening

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Shenzhen Kisshealth Biotechnology Co., Ltd

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Keypath P16 Protein Marker ICC Immunoassay Test Kit Cervical Cancer Screening

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Brand Name :	KISSH
Model Number :	K104
Certification :	CE
Price :	Negotiable
Payment Terms :	T/T
Delivery Time :	3 days

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Keypath P16 Protein Marker ICC Immunoassay Test Kit Cervical Cancer Screening

Keypath p16 Immunoassay Test Kit(ICC)

Introduction

p16 Antibody Reagent is an important marker for cervical cancer screening and diagnosis.

The p16^INK4a detection technology is a new detection method joint recommended by CAP and ASCCP.

There’s close relationship between p16 and cervical cancer.

Persistent HPV infection produces viral oncogenic protein E7, which binds to host cell PRB, releases transcription factor E2F, interferes with the cell cycle, and causes cells to continue to differentiate and develop precancerous lesions.

Principle

Based on the principle of specific binding between immunological antigen and antibody, the antibody is combined with enzyme-labeled chromogenic system to form a complex, and enzyme substrate (chromogenic agent) is added to make it chromogenic to locate and characterize the antigen to be detected. The location of cell staining is nucleus/cytoplasm.

P16 is one of the cell cycle regulatory proteins, also known as "mitosis inhibitor". Its role is to competitively bind CDK4/6 with cyclin D, and stop

the process of cells from G1 to S, thus negatively regulating mitosis. In tumor cells, gene mutation or deletion often leads to the increase of p16

expression, but the cell cycle can not be regulated. This antibody is mainly used in tumor research.

Advantages

The detection is with statistical significance by improved sensitivity and specificity.
Reduce workload, improve image reading efficiency, and reduce missed diagnosis rate.
Reduce referral rates for colposcopy and reduce overtreatment.
Whether p16 staining is positive or not indicates transient or persistent HPV infection, and p16-positive cells prompt the cytology doctor to review the liquid-based results.

Packaging

25 tests/kit ,50 tests/kit ,100 tests/kit

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